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Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates
1039/D4CB00130C
1186/s13036-019-0188-x
Methods 2019
Keywords: Cross-conjugation
DBM-PEG4-DBCO-NHCO AAD-5539 Impact of cathepsin B-sensitive triggersReferences: 1) Patterson, J. T.; et al. Chemically generated IgG2 bispecific antibodies through disulfide bridging. Bioorg. Med. Chem. Lett. 2017, 27(16), 3647 3652. DOI: 10. 1016 j. bmcl. 2017. 07. 021 Keywords: Bispecific Antibodies; Site specific Conjugation; Click Chemistry; DBCO 2) Patterson, J. T.; et al. PSMA targeted bispecific Fab conjugates that engage T cells. Bioorg. Med. Chem. Lett. 2017, 27(24), 5490 5495. DOI: 10. 1016 j. bmcl. 2017.
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